Meltdown science combines the synergistic fat burning power of beta andrenergic agonists (MethylSynephrine) and alpha andrenergic antagonists (Yohimbine HCl, alpha-Yohimbine and 11-Hydroxy Yohimbine). In simpler terms it activates fat burning mechanisms in your body while simultaneously blocking the internal biochemistry that prevents you from burning fat by guarding one of the body’s key fat burning hormones called Norepinephrine (NE). When fat burning is both promoted and protected at the same time we call this effect synergistic. So, instead of 9 (activation factor) + 8 (protection factor) equaling 17 on the fat burning scale, this synergistic combination has a geometric effect of 72! Meltdown is 117% to 273% more potent than caffeine plus ephedrine! It is the most powerful university researched fat burner ever! It increases glycerol by 69%, norepinephrine up to 93%, free fatty acids by 41% and thermogenesis by 29%! This product burns fat while sparing lean muscle and shifts metabolism to burn 56% more fat! The powerful fat loss agent, 11-hydroxy yohimbine is of great interest here because regular yohimbine yields a roughly 32% increase in the fat burning hormone, NE. Compare this to 11-Hydroxy Yohimbine that yields an even more impressive research proven 56% increase in the potent fat burning hormone, NE. We are only now just studying how the combination of the other Yohimbine compounds in Meltdown work in concert to increase NE even further. With the combined effect of alpha-Yohimbine and 11-hydroxy Yohimbine contained in Meltdown blocking both alpha-1 and alpha-2 receptors, my hypothesis is that we are looking at a 81%+ increase in NE! Research indicates that 11-hydroxy Yohimbine has a potent alpha-2 adrenergic receptor affinity that significantly increases lipid metabolism. 11-Hydroxy Yohimbine exhibits a 10 fold increase in the binding ability to alpha-2 adrenergic receptors. The half-life of 11-hydroxy Yohimbine is approximately 8 to 11 hours compared to Yohimbines two hour half-life. 11-Hydroxy Yohimbine offers definite advantage over Yohimbine in alpha-2 adrenergic receptors binding affinity and the longer half life in blood. The body converts Yohimbine to 11-hydroxy metabolite in the liver. Consequently, it is Meltdowns unique Yohimbine Tri-Matrix that works synergistically to increase unmatched norepinephrine- induced fat burning in both potency and duration of action. The active Methyl PEA isomer, R-beta Methylphenylehtylamine found botanically in nature and found also in chocolate, is a simpler form called PEA has been called the love compound. Think of Meltdowns R-beta Methylphenylehtylamine as the love compound in overdrive dramatically enhancing the sexual experience and many other aspects of fat loss and is trademarked by VPX as Craving Control and Mind Control Matrix for its potent ability to shut down appetite and eliminate carbohydrate cravings. MTTA is another really impressive research proven compound that causes apoptosis or systematic death to fat cells. Meltdown is also designed to increase mental clarity and mood with minimal jitteriness while burning fat at an unprecedented rate.